Long term side effects from PPIs

Proton pump inhibitors (PPIs) like Prilosec and Nexium are great over-the-counter products used to treat heartburn that occurs 2 or more days a week. PPIs block acid secretion in the stomach. These agents are very effective with minimal side effects. However, vitamin B12 deficiency, pneumonia, low magnesium levels, and bone fractures are potential side effects associated with long-term use. It is important to talk to a doctor before using these agents long-term.